| 1. | Research progress on prion and prion disease therapy
朊病毒和朊病毒疾病治疗的研究进展 |
| 2. | Prion diseases are always fatal , often , however , not until months after the outbreak of the disease
致病性的朊病毒蛋白质在脑中沉积并损伤脑组织。 |
| 3. | There is currently no treatment for prion diseases , which include cjd in humans and boine spongiform encephalopathy ( bse ) in cattle
目前还没有普粒子疾病的治疗办法，包括人类的克雅氏病（ cjd ）和牛脑海绵状病（疯牛病， bse ） 。 |
| 4. | The evidence is accumulating that prion diseases are due to proteins which change their conformation irreversibly during an association reaction , perhaps by mechanisms related to amyloid accumulation
越来越多的证据指出蛋白感染素疾病(如狂牛病)是因为蛋白质结合过程中其构型产生不可逆的改变，可能是由类淀粉体堆积相关的机制造成。 |
| 5. | The prototypic prion disease found is scrapie . the epidemic of bse in england and the newly found vcjd in human attracted more attention to prion diseases and the disease - causing proteins
羊瘙痒症是最早发现的朊蛋白病，而疯牛病在英国的流行以及新近发现的新变种的人类雅各布氏病引起研究者们对朊蛋白疾病及其致病蛋白的更大关注。 |
| 6. | A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins , creating the " seeds " that allow fatal brain illnesses to quickly spread , new brown uniersity research shows
布朗大学最新研究显示，有一种蛋白可能是朊毒病中关键蛋白，裂解感染性蛋白生成“种子”片段，然后侵袭脑组织致宿主迅速死亡。 |
| 7. | The facts that cellular prion protein is extensively distributed among tissues , its high similarity in different species and its indispensability in prion diseases development established its importance in the study of prion diseases
细胞型肮蛋白（ prpc ）在组织内分介广泛、在物种问高度保守并且在肮蛋白疾病的发生中不可或缺，这些特点决定了它在肮蛋白疾病研究中的重要地位。 |
| 8. | The propagation mechanism of the prion diseases is widely accepted that prpsc transforms prpc into the pathological form and more and more prpsc will gradually be produced and forms larger fibrillar aggregates . when a critical level of prpsc has accumulated , the neurons die , resulting in large vacuoles . the affected brain regions become sponge - like in appearance , hence the name spongiform encephalopathies to describe all prion diseases
目前普遍接受的朊蛋白疾病发生机制为prpsc转化prpc为致病形式，致使越来越多的致病蛋白形成并堆积成越来越大的纤维状聚集物，当致病蛋白聚集到一定程度，造成神经元死亡而使受累脑区呈现海绵样空洞，这也就是为什么用海绵样脑病来描述所有的肮蛋白疾病。 |
